09/10/2017 - 13:45 - 14:40
Apresentações |
16508 - ADVANCED MATERNAL AGE AND ITS ASSOCIATION WITH PLACENTA PRAEVIA AND PLACENTAL ABRUPTION: A META-ANALYSIS
KATRINI GUIDOLINI MARTINELLI - ENSP/FIOCRUZ, SILVANA GRANADO NOGUEIRA DA GAMA - ENSP/FIOCRUZ, ÉRICA MARVILA GARCIA - UFES, EDSON THEODORO DOS SANTOS NETO - UFES
Objective: To investigate the existence and magnitude of the association between Advanced Maternal Age (AMA) and occurrence of placenta praevia (PP) and placental abruption (PA) among nulliparous and multiparous women through a meta-analysis. Materials and methods: We searched articles published between January 1, 2005 and December 31, 2015, in any language, in the following databases: PubMed, Scopus, Web of Science, and LILACS, which grouped women into two age categories, up to 34 years and 35 years or older. The Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analyses was used to evaluate the methodological quality of the studies, the I² method proposed by Higgins to measure heterogeneity among the studies, the random effects model to calculate the Odds Ratio (OR), and the meta-regression model to find possible covariates associated with heterogeneity among the studies. The protocol of this systematic review was registered in the PROSPERO system. Results: Thirty-five studies met the criteria and were included in the meta-analysis. For both outcomes, an increase in age increased the magnitude of strength of association, and placenta praevia was shown to be more strongly associated with AMA than placental abruption. When stratified by parity, in nulliparous women considered older, the chance of PA was greater than in multiparous women. Conclusion: Due to the diversity of the populations studied and the different diagnostic methods, it was not possible to find a combined measure with the effect of age only, but the results suggest an association between AMA and PP/PA.
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