09/10/2017 - 16:50 - 18:10
Epidemiologia nutricional 1 |
16335 - NECK CIRCUMFERENCE HELPS IN THE CHARACTERIZATION OF ATHEROGENIC PROFILE IN MIDDLE-AGED INDIVIDUALS: THE BRAZILIAN LONGITUDINAL STUDY OF ADULT HEALTH (
BIANCA DE ALMEIDA-PITITTO - UNIFESP, ISIS T SILVA - FSP-USP, MARILIA L I FONSECA - FSP-USP, PAULO A LOTUFO - USP, ISABELA M BENSENOR - USP, SANDRA RG FERREIRA VIVOLO - FSP-USP
Objective: This sub-study of the Longitudinal Study of Adult Health (ELSA-Brasil) evaluated whether neck circumference (NC), an easily obtained measure, could be useful to identify a worse atherogenic profile based on biomarkers of inflammation, endothelial dysfunction, and fractions of lipoproteins, in middle-aged participants at low-to-moderate cardiovascular risk. Methods: A sample of 998 individuals (35-54years) without diabetes or cardiovascular disease was enrolled in this analysis. After being characterized as BMI<25kg/m2 or BMI≥25kg/m2, they were stratified into 2 categories of NC: normal or elevated (≥34cm for women and ≥37cm for men). Traditional risk factors, C-reactive protein (CRP), E-selectin and Vertical Auto Profile (VAP) lipid profile were compared by Student t-test. In linear regression models, associations of NC with biomarkers of atherogenic profile, adjusted for HOMA-IR, were tested. Results: Elevated neck circumference was found in 9% and 67% of the individuals with BMI <25 and ≥25 kg/m2, respectively. In both categories of BMI, but mainly in those with BMI ≥25 kg/m2 , those with elevated neck circumference had greater mean values of some of the traditional risk factors and novel biomarkers, as well as higher frequencies of abnormal risk factors. Linear regression models showed a direct and independent association between neck circumference and small-dense LDL and E-selectin, and an inverse independent association with HDL2, in both categories of BMI and adjusted for HOMA-IR index. Conclusion: Neck circumference may be a useful anthropometric measurement to identify a worse atherogenic profile independent of BMI and insulin resistance in middle-aged individuals at low-to-moderate cardiovascular risk level.
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